|
|
|
|
|
| Jicun Wang; Thomas Michelitsch; Arne Wunderlin; Ravi Mahadeva. |
| It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been proposed in the damage (fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some aging phenotypes such as fibrosis and premature aging, since terms such as ‘damage’ and ‘fault’ are not specified. Therefore we introduce here a specification of the underlying mechanism of aging and arrive at a novel theory: aging of the body is a result of the accumulation of Misrepair of tissue. It emphasizes: a) it is Misrepair, not the... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Evolutionary Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2988/version/2 |
| |
|
|
| Jicun Wang; Thomas Michelitsch; Arne Wunderlin; Ravi Mahadeva. |
| It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been proposed in the damage (fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some aging phenotypes such as fibrosis and premature aging, since terms such as ‘damage’ and ‘fault’ are not specified. Therefore we introduce here a specification of the underlying mechanism and arrive at a novel theory: aging of the body is a result of the accumulation of Misrepair of tissue. It emphasizes: a) it is Misrepair, not the original... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Evolutionary Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2988/version/1 |
| |
|
|
| Jicun Wang; Thomas Michelitsch; Arne Wunderlin; Ravi Mahadeva. |
| It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been proposed in the damage (fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some aging phenotypes such as fibrosis and premature aging, since terms such as ‘damage’ and ‘fault’ are not specified. Therefore we introduce here a specification of the underlying mechanism of aging and arrive at a novel theory: aging of the body is a result of the accumulation of Misrepair of tissue. It emphasizes: a) it is Misrepair, not the... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Evolutionary Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2988/version/3 |
| |
|
|
|
